8.The G-protein alpha-subunit activates adenylyl cyclase as one primary target. What does this enzyme do?
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How does the activated alpha subunit of G-protein activate its downstream target adenylyl cyclase? The alpha subunit phosphorylates adenylyl cyclase. The alpha subunit binds to a channel in the ER membrane to increase Ca++ in the cytosol. The alpha subunit converts ATP to cAMP. The alpha subunit binds directly to adenylyl cyclase, which remains active until the alpha subunit disassociates.
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