A 29-year-old woman with type 1 diabetes mellitus comes to the physician for a follow-up examination. At her last visit 3 weeks ago, she was found to have an increased serum creatinine concentration and proteinuria. She was also diagnosed with hypertension. Which of the following processes is most likely to occur in the remaining nephrons in this patient? A) Decreased filtration fraction B) Decreased vasoconstriction in the efferent arterioles C) Decreased vasodilation in the afferent arterioles D) Increased excretion of potassium E) Increased intraglomerular capillary pressure
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In diabetic nephropathy, hyperglycemia leads to increased pressure and flow through the glomeruli, causing damage and sclerosis. The body attempts to compensate for this damage by increasing the filtration rate in the remaining nephrons, which further increases Show more…
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