A gene is structured as follows: Exon 1 - Intron 1 - Exon 2 - Intron 2 - Exon 3 - Intron 3 - Exon 4 - Intron 4 - Exon 5. If splicing occurs at all the possible places, it can, what information will the final protein contain? ☐ Exon 1 - Intron 3-Exon 5 ☐ Intron 1 - Intron 2 - Intron 3 - Intron 4 ☐ Intron 1-Intron 2-Exon 3 ☐ Exon 1 - Exon 2 - Exon 3 - Exon 4 - Exon 5 ☐ Exon 1 - Intron 1 - Exon 2 - Intron 2 - Exon 3 - Intron 3 - Exon 4 - Intron 4 - Exon 5
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Splicing removes introns from the pre-mRNA, leaving only exons to be translated into protein. Show more…
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Consider the following gene (H-1-I-2-J-3-K-4-L) Exon H - Intron 1 - Exon I - Intron 2 - Exon J - Intron 3 - Exon K - Intron 4 - Exon L. The gene undergoes 2 splice-site mutations, one causes Intron 4 to be retained, and another that causes skipping of Exon K. Write the correct structure of the translated protein. Note your answer should look like this: (H-1-I-2-J-3-K-4-L) Letters represent exons and numbers represent introns.
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Question 4) The gene X you are studying has 3 exons and 2 introns with the following sizes: size exon 1: 2 kb exon 2: 1 kb exon 3: 3 kb intron 1: 2 kb intron 2: 3.5 kb 4.1. Draw a diagram of the DNA using the line below. Below your diagram, draw the mature, processed mRNA (roughly to scale). Where appropriate, indicate the location of each intron and exon, the 5'UTR, the 3'UTR, the 5' cap, the start codon, the stop codon, the polyA tail, splicing regulatory sequences. ______________________________________________________________________________________________________ 4.2. In a study investigating changes induced by RNA splicing mutations, you suspect that gene X is mis-spliced in the patient samples. The sequencing results predict that there are two independent alterations: (i) a retention of intron 1 and (ii) a skipping of exon 2. You are tasked with designing primer pairs to run a quantitative RT-PCR (to yield an amplicon product of about 100-150 bp in length) to distinguish these 2 abnormal transcripts from the normal mature transcript (3 exons). How will you design these primer pairs? Draw the scheme with locations of the primers along gene X.
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A human gene was initially identified as having three exons and two introns. The exons are 456, 224, and 524 bp, whereas the introns are 2.3 kb and 4.6 kb. Required: a. Draw this gene, showing the promoter, introns, exons, and transcription start and stop sites. b. Surprisingly, this gene is found to encode not one but two mRNAs that have only 224 nucleotides in common. The original mRNA is 1204 nucleotides, and the new mRNA is 2524 nucleotides. Use your drawing to show how this one region of DNA can encode these two transcripts.
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