A mother brings her child to the pediatric clinic because of irritability, loss of appetite, low-grade fever, pallor, and leg pain. Blood tests reveal anemia, thrombocytopenia, and an elevated leukocyte count with atypical lymphocytes. fever, pallor, and complaints that his legs hurt. Blood tests reveal anemia, thrombo-cytopenia, and an elevated leukocyte count with atypical lymphocytes. A diagnosis of ALL is confirmed A. What is the origin of the anemia, thromboey-penia, elevated leukocyte count, and atypical lymphocytes seen in this child? B. Explain the cause of the child's fever, pallor, increased bleeding, and bone pain. C. The parents are informed that the preferred treatment for ALL consists of aggressive chemotherapy with the purpose of achieving a remission. Explain the rationale for using chemotherapy to treat leukemia. D. The parents are told that the child will need intrathecal chemotherapy administered by a lumbar puncture. Why is this treatment necessary? 2. A 36-year-old man presents to his health care clinic with fever, night sweats, weight loss, and a feeling of fullness in his abdomen. Subsequent lymph node biopsy reveals a diagnosis of NHL. A. Although lymphomas can originate in any of the lymphoid tissues of the body, most originate in the lymph nodes, and most (80% to 85%) are of B-cell origin. Hypothesize as to why B cells are more commonly affected than T cells. B. Monoclonal antibodies are being used in the treatment of NHL. Explain how these agents exert its effect and why they are specific for B-cell lymphomas.