Alleles for Sickle Cell Anemia occur at higher rates in some populations compared to others. Here, please explain what Sickle Cell Anemia is, how it is inherited, and why in spite of any negative side effects has it persisted as a trait among humans. Be as detailed as possible. You may even include a punnet square in your answer.
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This mutation results in the production of abnormal hemoglobin known as hemoglobin S (HbS). Show more…
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In humans, sickle cell anemia is caused by a mutation in a hemoglobin gene. This mutation affects the red blood cell shape, but it also affects oxygen-carrying ability and resistance to malaria. This gene is best described as: incompletely dominant pleiotropic imprinted or epigenetic polygenic
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Sickle-cell anemia is a genetic disease. In the U.S., it is especially prevalent among blacks: one person in four hundred suffers from it. The disease is controlled by one gene-pair, with variants $A$ and $a,$ where $a$ causes the disease but is recessive: $$\begin{array}{l}{A / A, A / a, a / A-\text { healthy person }} \\ {a / a-\text { sickle-cell anemia. }}\end{array}$$ (a) Suppose one parent has the gene-pair $A / A$ . Can the child have sickle- cell anemia? How? (b) Suppose neither parent has sickle-cell anemia. Can the child have it? (c) Suppose both parents have sickle-cell anemia. Can the child avoid having it? How?
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