An autosomal recessive condition has a population frequency of 1:150 000. A woman who has an affected brother has a partner with no family history. What is their risk of having an affected child? A 1/387 B 1/774 C 1/1161 D 2/1161 E 1/2322
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This is based on the Hardy-Weinberg principle, which states that the frequency of carriers is 2pq, where p is the frequency of the normal allele and q is the frequency of the affected allele. Since the condition is rare, we can approximate p as 1 and q as the Show more…
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