Bacitracin blocks the transport of NAG and NAM across the cytoplasmic membrane to the cell wall. Like other antimicrobials that block cell wall synthesis, this would result in weak cell walls and the inability to synthesize flagella, inhibition of nucleic acid synthesis, less protein synthesis, and cell lysis due to the effect of osmotic pressure.
Which of the following antimicrobial drugs would likely be useful to treat a methicillin-resistant Staphylococcus aureus infection because it effectively blocks initiation of translation?
- praziquantel
- azoles
- oxazolidinones
- mupirocin
Polymyxin is effective against only some Gram-negative bacteria; therefore, it is considered a narrow-spectrum drug.