BCR-ABL gene fusion is a common gene translocation in chronic myelogenous leukemia. This translocation (as shown in the diagram) generates an oncoprotein that contains one portion of the BCR and ABL proteins. For example, we know that such a translocation occurred in 1 out of 3 leukemia tumor samples. Do you have any approaches to define which tumor has the translocation? Please describe at least two strategies.
Added by Tammy W.
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Step 1: Understand the molecular mechanism of BCR-ABL gene fusion in chronic myelogenous leukemia, where the translocation generates an oncoprotein containing portions of the BCR and ABL proteins. Show more…
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