Question

Below is a partial pedigree of hemophilia in the British Royal Family descended from Queen Victoria, who is believed to be the original "carrier" in this pedigree. Analyze the pedigree and indicate which females are also certain to be carriers. What is the probability that Princess Irene is a carrier?

          Below is a partial pedigree of hemophilia in the British Royal Family descended from Queen Victoria, who is believed to be the original "carrier" in this pedigree. Analyze the pedigree and indicate which females are also certain to be carriers. What is the probability that Princess Irene is a carrier?
        
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Biology for AP Courses
Biology for AP Courses
Julianne Zedalis, John Eggebrecht
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Below is a partial pedigree of hemophilia in the British Royal Family descended from Queen Victoria, who is believed to be the original "carrier" in this pedigree. Analyze the pedigree and indicate which females are also certain to be carriers. What is the probability that Princess Irene is a carrier?
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Below is a partlal pedigree of hemophilia in the British Royal Family descended from Queen Victoria, who is belicved to be the original "carrier" in this pedigree. Analyze the pedigree and indicate which females are also certain to be carriers. What is the probability that Princess Irene is a carrier?

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There is a $50-50$ chance that the queen carries the gene of hemophilia. If she is a carrier, then each prince has a $50-50$ chance of having hemophilia independently. If the queen is not a carrier, the prince will not have the disease. Suppose the queen has had three princes without the disease, what is the probability the queen is a carrier?

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Famously, Queen Victoria's descendants were plagued by hemophilia, an X-linked recessive disease. The present-day monarch of the United Kingdom, Queen Elizabeth, is a direct descendant of Queen Victoria: Elizabeth's great-grandfather was Victoria's son (King Edward VII) who was not a hemophiliac. What is the chance that Elizabeth is a carrier for hemophilia? Explain your reasoning.

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Transcript

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00:01 In order to answer this question, let's talk about inheritance.
00:04 Below is a partial pedigree of hemophilia in the british royal family descended from queen victoria, who is believed to be the original cagor in this pedigree.
00:15 Underlies the pedigree and indicate which females are also certain to be caggers.
00:21 It means you want to know which of them or which of the females were also heterocygote for the hemophilia galile.
00:28 So in this case, this trait is ex -linked.
00:31 So in case of females, the homocygous lominant and the heterocygote are normal, while the homozygous recessive, like this, is for a hemophilia woman, like in victoria, or well, not, victoria is a co -heterocytocytocytoccus.
00:51 This is in victoria, okay? now, in case of males, males are either like this or like this.
01:04 So in this case, let's see.
01:06 You have the queen victoria was a carrier, so it means that she was like this.
01:15 He throws like this.
01:16 Okay? now, let's look here for albert first.
01:20 Albert is healthy, so it means that he is like this.
01:25 Remember that a person inherits one allele from each parent.
01:27 So in this case, for empress victoria, she inherited or she's xx first.
01:33 So it means that she inherited one alil from the father and one alir from the mother.
01:38 In this case, the father for sure is going to transmit the dominant anil.
01:45 So she must have at least one dominant ali.
01:48 Okay.
01:50 And this second alien should come from the model.
01:52 So the mother can transmit either this allele or this allele.
01:56 So empress victoria can be homozygous dominant or heterocylusicles.
01:59 But as there is no more information about this, then we cannot be sure that empress victoria is heterocylus for sure.
02:06 So practically empress victoria is not heterocylus for sure.
02:09 What about alice of hess? it means this woman here.
02:15 Well, in this case, again, as she is the sister of empress victoria, she is going to have at least one dominant allele like this, right? because the father can only transmit dominant alil to his off -prens to his daughter specifically.
02:31 Now, but in this case it says that frederick has the mutant allele, or practically that he has hemophilia.
02:37 So it means that his genotype is like this.
02:40 Now, again, a person in his humanoid is like this.
02:42 Here is one adil from each parent.
02:43 When you have a son, the white chromosome always comes from the father because mothers don't have a white chromosome...
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