00:01
Okay, i want to answer this question, let's talk about botulid toxin.
00:05
Remember that if this is your motor neuron, this is your axon terminal, normally here you have vesicles containing acetyl calling.
00:14
Okay? when depolarization occurs in this motor neuron, this membrane is going to be depolarized, and this is going to be opening of voltage -gated calcium channels, and calcium ions are going to get inside of the axon terminal, and it is going to allow exocytosis of these basicles containing acetylcholine.
00:34
A acetylcholine is going to be released.
00:37
Here we're going to have a sarcolema, that is the cell membrane of the skeletal muscle, and you're going to have here the nicotine receptors that are channel ions or ion channels that are normally closed.
00:50
Once acetylcholine binds to these nicotinic receptors, these ion channels are going to open and they are going to allow the influx of sodium ions inside of a shark inside of the muscle cell and it is going to cause the polarization of the muscle cell and muscle contraction.
01:09
Okay, so what does botolinon toxin does? well, botulinin toxin is going to prevent this process of exocytosis, so acetylcholine is not going to be released to this space here that is a synaptic cleft.
01:22
Okay, so it says botulinotoxin acts by binding presynactic inhibiting the acidyl colon.
01:30
And this mechanism of action would impact a cell's capacity to carry out.
01:34
And the first plan is going to be synaptic transmission.
01:43
Then we have question number two, or i'm sorry, a blank number two that says, this organelles pumps out excess water...