Chemotherapy drugs such as vincristine and colchicines disrupt mitosis by binding to tubulin (the subunit of microtubules) and interfering with microtubule assembly and disassembly. Explicitly referring to Mitosis, explain what mitotic structure is targeted by these drugs, and what effect would this have on cell division?
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One of the key structures involved in this process is the mitotic spindle, which is composed of microtubules. The mitotic spindle is responsible for organizing and separating the chromosomes during cell division. Vincristine and colchicines are chemotherapy drugs Show more…
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Chemotherapy drugs such as vincristine and colchicines disrupt mitosis by binding to tubulin (the subunit of microtubules) and interfering with microtubule assembly and disassembly. Exactly what mitotic structure do these drugs target, and what effect would that have on cell division? a. The drugs bind tubulin and inhibit the binding of spindle to the chromosome. This can arrest the cell cycle. b. The drugs bind the tubulin, which leads to an error in the chromosome separation. This could lead to apoptosis. c. The drugs bind the tubulin, thereby inhibiting their division in S-phase. This inhibits cell division. d. The drugs bind the spindle fiber and hinder the separation of chromatins. This promotes the division spontaneously.
One way to cure cancer is for patients to take chemotherapy drugs such as vincristine and colchicine. These cancer drugs disrupt mitosis by binding to tubulin (the subunit of microtubules) and interfering with microtubule assembly and disassembly. Exactly what mitotic structure is targeted by these drugs? What effect would they have on cell division? How does their action cure cancer?
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