Mutated DNA Sequence TACACATTGGCGACGACT... (Circle the change) What's the mRNA sequence? What will be the amino acid sequence? Will there likely be effects? What type of mutation is this? Evidence? 1. Which type of mutation is responsible for new variations of a trait? Explain your reasoning for EACH. Frameshift and missense mutation can bring the new. Frameshift and missense mutation can bring the new variation of traits, The deletion (lose of base) or insertion (addition of base) will bring the frameshift mutation resulting in change of frame reading When there is substitution (one base is substituted by other) of base takes place which changes the amino acid is called MISSENSE MUTATION
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Identify the mutated DNA sequence: The given sequence is TAC^c^TT G G € G ^ € G ^ € T_. The mutated part is marked with symbols, so the mutated DNA sequence is TACcTTGGGGGT. Show more…
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Mutated DNA Sequence #2 T A C G A C C T T G G C G A C G A C T … What’s the mRNA sequence? (Circle the change) What will be the amino acid sequence? Will there likely be effects? What type of mutation is this? ________________________________
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Mutation # | DNA Sequence change | mRNA codon change (original > mutant) | Amino acid change (original > mutant) | Type of mutation (silent, missense, nonsense) --- | --- | --- | --- | --- 1 | Coding ATA -> ATC, Template TAT -> TAG | AUA > AUC | Ile > Xxx | 2 | Coding TAT -> TAA, Template ATA -> ATT | UAU > NNN | Xxx > Xxx | 3 | Coding AGT -> AGG, Template TCA -> TCC | NNN > NNN | Xxx > Xxx | D. Imagine a ‘G’ were inserted at the beginning of the original coding DNA sequence from part B as indicated here: 5'-GACG ATA TAT AGT GCT-3' 1. Write out the resulting mRNA and amino acid sequence. New mRNA = 5'- GAC GAU AUA UAG UGC U-3' New amino acid sequence = Asp Asp 2. What kind of mutation has occurred? Highlight 3. Do you think this mutation will affect the function of the protein? Why or why not? Highlight 3. Unrepaired DNA damage can lead to mutations. a. DNA damage can be caused by mutagens in the environment. Give an example of a mutagen and the kind of DNA damage it causes. Example Mutagen | Type of damage caused by the mutagen b. A type of DNA damage called ‘depurination’ is a common, spontaneous form of DNA damage in which the nitrogenous base of a purine nucleotide is lost. How does the loss of the base affect the genetic information? Highlight
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Mutated DNA Sequence #1: T A C A C C T T G G G A C G A C T What will be the corresponding mRNA sequence? What will be the amino acid sequence? Will there likely be effects? What kind of mutation is this?
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