Consider the following metabolic pathways: Pyruvate ---> Acetyl CoA -> Krebs cycle OR Pyruvate ---> Lactate (Lactic acid) If Patrick's enzyme responsible for converting pyruvate to acetyl CoA was inhibited, what would happen? [Select]
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Step 1: The enzyme responsible for converting pyruvate to acetyl CoA is pyruvate dehydrogenase. Show more…
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If LDH was mutated or inhibited, what is a likely result under anaerobic conditions? Generation of ATP would slow due to increased pyruvate. Oxamate product would build up in glycolysis. Lactic acid buildup would occur and be immediately toxic to the cells. Pyruvate and lactate would alternate in production.
Akhand S.
Pyruvate carboxylase converts pyruvate to oxaloacetate. The resulting oxaloacetate can serve as a precursor for anabolic pathways, such as gluconeogenesis. Under other conditions, pyruvate carboxylase can serve to carry out an anaploerotic reaction to replenish oxaloacetate in the citric acid cycle. Answer the following questions about the regulation of these two potential fates of oxaloacetate: a. What effect does acetyl CoA have on the activity of pyruvate carboxylase? [ Select ] b. Which of the following statements describes a condition under which acetyl CoA would accumulate? (note: PDHC stands for pyruvate dehydrogenase complex, CAC stands for citric acid cycle) [ Select ] c. Under which condition is the oxaloacetate produced by pyruvate carboxylase most likely to enter the citric acid cycle rather than being diverted to an anabolic pathway? [ Select ]
Madhur L.
Pyruvate dehydrogenase is the entry point for the glycolytic product pyruvate into oxidative metabolism (the citric acid cycle and oxidative phosphorylation). Because it occupies such an important checkpoint in metabolism, it is tightly regulated. (a) Determine whether the following conditions promote entry into oxidative metabolism or limit entry into oxidative metabolism. The following abbreviations may be used: PDH is pyruvate dehydrogenase; PDK is pyruvate dehydrogenase kinase; PDP is pyruvate dehydrogenase phosphatase.- Low O2 levels, PDK active- High O2 levels, active PDH- High O2 levels, PDK inhibitor present- High O2 levels, inactive PDH- High O2 levels, PDK activeb) What is the fate of pyruvate (in a human) if a person has a phosphatase deficiency- It is processed to lactate.- It is processed to acetyl-CoA.- It is processed to ethanol.
Adi S.
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