Does negative selection (clonal deletion) in thymus express a TCR with too high an affinity for self-antigen + self-MHC?
Added by Randy W.
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Step 1: T cells develop in the thymus and undergo selection processes to ensure self-tolerance and functional competence. Show more…
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Promiscuous gene expression controlled by AIRE expressed by mTECs leads to the deletion of autoreactive thymocytes. Promiscuous gene expression controlled by Fezf2 expressed by mTECs leads to the deletion of autoreactive thymocytes. Negative selection leads to the deletion of Tregs. Negative selection ensures self-tolerance. None of the above.
Sri K.
How do positive and negative selection lead to a population of T cells that react to MHC molecules in association with nonself antigens, but not to self antigens?
In T-cell development, negative selection selects what? a. T-cells that would be more useful as B-cells b. thymocytes that have too great a binding affinity for MHC/self peptide c. T-cells with receptors that would recognize negatively charged peptides d. T-cells that should be fast-tracked to inducing neuron apoptosis e. only recognize antigen when it is presented on self-MHC molecules
Adi S.
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