In T-cell development, negative selection selects what? a. T-cells that would be more useful as B-cells b. thymocytes that have too great a binding affinity for MHC/self peptide c. T-cells with receptors that would recognize negatively charged peptides d. T-cells that should be fast-tracked to inducing neuron apoptosis e. only recognize antigen when it is presented on self-MHC molecules
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Step 1: T-cell development involves negative selection, which eliminates T-cells that could potentially cause autoimmune reactions by recognizing self-antigens too strongly. Show more…
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During T cell maturation, the positive selection process makes sure that T cells can bind to "self" antigen T cell receptors B cell receptors MHC molecules
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MHC restriction is best described as: a. elimination of thymocytes bearing T-cell receptors that are unable to interact with self-MHC molecules b. preferential survival and proliferation of thymocytes that survive negative selection c. T-cell recognition of a peptide antigen only when it is bound to a particular form of MHC molecule d. a state of non-responsiveness to a peptide antigen e. a condition in which either MHC class I or class II molecules are not expressed on cells.
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Upon encountering an antigen, only T-cells with a specific T-cell receptor are activated. This is an example of: (A) innate immunity. (B) a cytotoxic T-cell response. (C) humoral immunity. (D) clonal selection.
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