Draw out an s r f model of the sickle cell disease include...

Draw out an SRF model of the sickle-cell disease. Include the beta-globin gene, nucleotide sequence, allele, hemoglobin protein, normal/sickled red blood cells as structures. Make the structures specific to the system. Your model should show how variation at the genetic level results in phenotypic variation. Therefore, you should have more than 1 box with a phenotype to show this variation. If your genotype is homozygous for the sickle cell allele, what type(s) of red blood cells will you have? ["True" or "False"] Sickled red blood cells ["True" or "False"] Normal red blood cells

Transcript

00:01 Okay, so the effect of rna on protein level, i'm just going to label them one, three five, is the mutation in the hbb gene in sickle cell anemia changes one of the amino acids, the building blocks of the proteins, and the beta chain of hemoglobin.

00:22 This defect causes the hemoglobin protein to stick together and form stiff fibers.

00:28 These fibers to store the shape of the red blood cells and make them more fragile.

00:33 Sickle cell anemia messenger rna directs the synthesis of a normal alpha and sickle beta chains.

00:41 B -thalassemia messenger rna directs to synthesis of normal alpha and beta chains, but the amount of b -globulin synthesized and was markedly reduced.

00:50 It's basically sticky cells.

00:58 So as far as there is any effect at the cellular level, hemoglobin is a protein in red blood cells that carries oxygen throughout the body.

01:05 With sickle cell disease, the hemoglobin forms to stiff rods within the red blood cells.

01:11 So the answer short is yes, it causes changes.

01:19 These changes in shape of the red blood cells, the cells are supposed to be disshaped, but the changes in them to a crescent or sickle shape, hence the name.

01:28 Normally, the flexible round red blood cells move easily through the blood vessels.

01:32 In sickle cell anemia, the red blood cells are shaped like sickles, and they're rigid, sticky, and can get stuck...

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