Drugs such as AZT work by inhibiting the function of reverse transcriptase. Integrase Strand Transfer Inhibitors (INSTI) are a class of antiretroviral drugs designed to block the action of integrase, a viral enzyme that inserts the viral genome into the DNA of the host cell. Sketch a model showing how AZT and INSTI work.
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Reverse transcriptase is an enzyme used by retroviruses, like HIV, to convert their RNA genome into DNA. Integrase is another enzyme that facilitates the integration of this viral DNA into the host cell's DNA. Show more…
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39. (12pts) In the figure below there is a structural formula of AZT - the first ever anti-HIV drug affecting reverse transcription of the viral genome. AZT 1) The role of HIV reverse transcriptase is to convert viral RNA into double stranded DNA . 2) AZT resembles ‐‐‐ nucleoside with one modification, namely is re-placed with ‐‐‐‐‐‐‐‐‐‐. 3) Now recall and describe briefly how the Sanger DNA sequencing works (also called a chain terminator method). 4) Finally, based on 1)-3) explain the mechanism through which the drug AZT helps HIV-infected patients.
Adi S.
AZT is a drug that is commonly used to fight HIV infection. The active component of AZT is a nitrogenous base that mimics thymine. Normal nucleotides CANNOT covalently bond to the thymine mimic. HIV's reverse transcriptase enzyme will use the thymine mimic instead of using thymine, whereas our DNA polymerase will not make this mistake. What is the most likely explanation for how AZT prevents HIV replication
Sri K.
HIV, the virus that causes AlDS, depends on an enzyme called reverse transcriptase to multiply. Reverse transcriptase reads a molecule of RNA and creates a molecule of DNA from it. A molecule of AZT, an anti-AlDS drug, has a shape very similar to (but a bit different than) that of the DNA base thymine. Propose a model for how AZT inhibits HIV.
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