Edward syndrome is characterized by heart defects, small cranial features, and intellectual disabilities caused by the presence of an extra chromosome 18. What is the most likely cause of this mutation? a. Duplication of chromosome 18 during S phase b. Autopolyploidy c. Nondisjunction during meiosis I d. Nondisjunction during mitosis e. All of the above could cause this disorder.
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This means that there are three copies of chromosome 18 instead of the normal two copies. This can occur due to errors during the formation of reproductive cells (meiosis) or during early cell division after fertilization (mitosis). Duplication of chromosome 18 Show more…
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2. A child with Edwards Syndrome has the karyotype shown. Children born with this disease are small, cognitively impaired, and die as infants due to heart failure. a. What is abnormal about the karyotype? b. Circle a homologous pair of chromosomes on the karyotype.
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