ESTROGEN (HORMONE) RECEPTOR LIGAND-BINDING ACTIVATION DOMAIN-when a ligand bind allows for...changes conformation of key alpha helices => activation status estrogen bound to receptor activates the complexestrogen absent/turned off gets stabilized (tamoxifen; antagonist) --> improper conformation therefore, receptor can't interact with co-factor
Added by Stephanie H.
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This binding event is the initial trigger for a series of conformational changes within the receptor protein. Show more…
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