Explain the function of positive and negative selection in T cell development. What would be the outcome if positive selection was not part of development? What would occur if negative selection was not part of development?
Added by David F.
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This process ensures that T cells are capable of recognizing and interacting with self-MHC molecules, which is essential for their function in the immune system. If positive selection was not part of development, the majority of T cells would not be able to Show more…
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In T-cell development, negative selection selects what? a. T-cells that would be more useful as B-cells b. thymocytes that have too great a binding affinity for MHC/self peptide c. T-cells with receptors that would recognize negatively charged peptides d. T-cells that should be fast-tracked to inducing neuron apoptosis e. only recognize antigen when it is presented on self-MHC molecules
Adi S.
A) In what way do the four double-negative stages of T-cell development demonstrate the organization of T-cell development according to spatial parameters? B) The affinity model can help explain the thymic selection paradox. What is the paradox, and is the affinity model the only way the paradox can be explained? C) Endogenous and exogenous superantigens can directly activate the host T-cell response. Why might a pathogen purposely invite a host T-cell response?
Shyam P.
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