Question

1. Given the following concentrations, use the Nernst equation to determine the equilibrium potentials for each ion. [inside] [outside] P K+ 130 8 1.0 Na+ 14 125 0.04 Cl- 10 110 0.45 Ca2+ 0.1 2 0.0001 2. Using the concentrations and relative permeabilities, use the G-H-K equation to calculate the Vm for a neuron at rest. 3. Assume that during an action potential the relative permeability to Na+ changes from 0.04 to 10 (i.e., the cell is suddenly more permeable to Na+ than to K+). Recalculate Vm to determine what voltage the membrane would attain under these conditions. 4. While recording from a neuron in Neurobiology lab, you notice that injecting 10 nA of current into the cell causes it to depolarize by 40 mV. You determine that it reaches 63% of that voltage change in 15 msec. Given this information, determine the following: ?m Rm

          1. Given the following concentrations, use the Nernst equation to determine the equilibrium potentials for each ion.
[inside] [outside] P
K+ 130 8 1.0
Na+ 14 125 0.04
Cl- 10 110 0.45
Ca2+ 0.1 2 0.0001

2. Using the concentrations and relative permeabilities, use the G-H-K equation to calculate the Vm for a neuron at rest.

3. Assume that during an action potential the relative permeability to Na+ changes from 0.04 to 10 (i.e., the cell is suddenly more permeable to Na+ than to K+). Recalculate Vm to determine what voltage the membrane would attain under these conditions.

4. While recording from a neuron in Neurobiology lab, you notice that injecting 10 nA of current into the cell causes it to depolarize by 40 mV. You determine that it reaches 63% of that voltage change in 15 msec. Given this information, determine the following:

?m

Rm

1. Given the following concentrations, use the Nernst equation to determine the equilibrium potentials for each ion.
[inside] [outside] P
K+ 130 8 1.0
Na+ 14 125 0.04
Cl- 10 110 0.45
Ca2+ 0.1 2 0.0001

2. Using the concentrations and relative permeabilities, use the G-H-K equation to calculate the Vm for a neuron at rest.

3. Assume that during an action potential the relative permeability to Na+ changes from 0.04 to 10 (i.e., the cell is suddenly more permeable to Na+ than to K+). Recalculate Vm to determine what voltage the membrane would attain under these conditions.

4. While recording from a neuron in Neurobiology lab, you notice that injecting 10 nA of current into the cell causes it to depolarize by 40 mV. You determine that it reaches 63% of that voltage change in 15 msec. Given this information, determine the following:

?m

Rm

Added by Nathaniel A.

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