Question

Heart conditions known as cardiomyopathies include two main subtypes. In hypertrophic cardiomyopathies, the heart muscle becomes stiff. Such disorders can be treated by drugs like verapamil, which block calcium channels. In a second class of cardiomyopathies, the heart muscle becomes dilated. These disorders are sometimes treated with the drug digoxin, which blocks Na$^+$ pumps and elevates intracellular Ca$^{2+}$ in cardiac muscle cells. Both types of disorder can be caused by mutations in the genes encoding troponin. Some of these mutations increase troponin's sensitivity to Ca$^{2+}$; other mutations reduce it. Based on the treatment protocols outlined, what type of mutation is responsible for hypertrophic cardiomyopathy? Choose one: A. mutations that either increase or decrease troponin's sensitivity to Ca$^{2+}$ B. mutations that decrease troponin's sensitivity to verapamil C. mutations that increase troponin's sensitivity to Ca$^{2+}$ D. mutations that decrease troponin's sensitivity to Ca$^{2+}$ E. mutations that decrease troponin's sensitivity to digoxin

          Heart conditions known as cardiomyopathies include two main subtypes. In hypertrophic cardiomyopathies, the heart muscle becomes stiff. Such disorders can be treated by drugs like verapamil, which block calcium channels. In a second class of cardiomyopathies, the heart muscle becomes dilated. These disorders are sometimes treated with the drug digoxin, which blocks Na$^+$ pumps and elevates intracellular Ca$^{2+}$ in cardiac muscle cells. Both types of disorder can be caused by mutations in the genes encoding troponin. Some of these mutations increase troponin's sensitivity to Ca$^{2+}$; other mutations reduce it. Based on the treatment protocols outlined, what type of mutation is responsible for hypertrophic cardiomyopathy?

Choose one:
A. mutations that either increase or decrease troponin's sensitivity to Ca$^{2+}$
B. mutations that decrease troponin's sensitivity to verapamil
C. mutations that increase troponin's sensitivity to Ca$^{2+}$
D. mutations that decrease troponin's sensitivity to Ca$^{2+}$
E. mutations that decrease troponin's sensitivity to digoxin

heart conditions known as cardiomyopathies include two main subtypes in hypertrophic cardiomyopathies the heart muscle becomes stiff such disorders can be treated by drugs like verapamil whi 62345

Added by Kristen G.

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