Human Leukocyte Antigen (HLA) polymorphisms play a critical role in transplantation compatibility, autoimmune disease predisposition, and immune response.
List at least three methods commonly used to detect HLA polymorphisms.
For each method, briefly describe its principle of operation and level of resolution (e.g., low, intermediate, or high resolution).
Explain how these methods can be combined to enhance diagnostic capabilities, particularly in complex cases such as ambiguous HLA typing or allele-level resolution.