In Cushing’s syndrome, a hyperactive adrenal gland causes elevated levels of which hormone?
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Step 1: Cushing’s syndrome involves overproduction of glucocorticoids by the adrenal cortex. Show more…
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Part A If the anterior pituitary is responsible for hyperthyroidism, the level of TSH will be reduced along with the levels of T3 and T4, which are the thyroid hormones; the level of TRH from the hypothalamus will be elevated. Part B In a nonfunctioning adenoma of the corticotrophs, which are the cells that secrete ACTH, the CRH level will be reduced, and the cortisol level will be reduced. Part C Cushing’s disease is caused by a pituitary adenoma, resulting in an increase in blood cortisol; Cushing’s syndrome is an elevated cortisol level as the result of some other cause. If a patient has an elevated cortisol level and they are found to have a tumor of the adrenal cortex, the condition would be diagnosed as Cushing’s syndrome.
Madhur L.
A dog's pituitary gland produces the hormone ACTH, which stimulates the adrenal glands to secrete cortisol. Cortisol helps regulate body weight, mineral balance, the structure of connective tissue, the production of white blood cells, and skin health. When cortisol levels are low, the pituitary gland secretes ACTH. When cortisol levels are high, the pituitary gland stops secreting ACTH. Based on this information, which of the following would most likely be the cause of elevated levels of cortisol in a dog? A. Undersized adrenal glands B. An excess of ACTH C. An inactive pituitary gland D. An immune response to the excess level of cortisol
Sri K.
A 32-year-old woman presented to the clinic complaining of weight gain, swelling in her legs and ankles, and a puffy face. She also recently developed hypertension and diabetes type 2. She noted poor short-term memory, irritability, excess hair growth (in women), a red-ruddy face, extra fat around her neck, fatigue, poor concentration, and menstrual irregularity, in addition to muscle weakness. Given her physical appearance and history, a tentative diagnosis of hypercortical function was made. Diagnostics included serum and urinary cortisol and serum adrenocorticotropic hormone (ACTH) levels. MRI revealed a pituitary adenoma. Question: How would you differentiate Cushing's disease from Cushing's syndrome?
Adi S.
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