In initiation of eucaryotic translation, which element within the mRNA sequence, determine solation of the start codon
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The start codon is typically AUG, which codes for the amino acid methionine. Show more…
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Eukaryotic mRNAs possess a 5'-cap that helps guide the ribosome to the first AUG, the codon where translation will start.
Adi S.
In eukaryotes, the 3' end of the mRNA is important in the initiation of translation because it contains Kozak sequences that aid in initiation of translation in the 5' to 3' direction. The 3' poly(A) tail and PABP bind initiation factor eIF4G, stabilizing the 5' end of the mRNA. eIF4A is attached to the 3' end and removes any secondary structure that might prevent translation. Translation occurs in the 5' to 3' direction.
How does the eukaryotic translation initiation complex locate the correct start codon? A. The General Transcription Factors locate the promoter, then help RNA polymerase enter the complex to form the preinitiation complex. B. The initiation complex moves the small ribosomal subunit through the 5' UTR, scanning for the Kozak sequence 5' ACCAUG-3'. C. The true start codon is the first ATG encountered downstream of the Shine-Dalgarno sequence. D. The pre-initiation complex moves the ribosome through the 3' UTR, scanning for the Kozak sequence.
Sri K.
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