In order to make it past the first checkpoint discussed in class, a cell that is committed to becoming a lymphocyte must be able to express what? (Note: If the cell makes it past this checkpoint, it will be called a Pre-B or Pre-T cell.)
MHC Class I
MHC Class II
One chain of its antigen receptor
Both antigen receptor chains
Once a cell has committed to differentiating along the lymphoid lineage and become a Pre-B/T cell, what will happen to the cell if it is unable to express a functional antigen receptor?
The cell will switch to differentiation along the myeloid lineage.
The cell will migrate to a lymph node looking for antigen in order to adjust the conformation of its nonfunctional antigen receptor.
The cell will undergo apoptosis.
The cell will revert to a stem cell state.
In the case of MHC-restricted T lymphocytes (which are the only T cells we have discussed thus far), strong recognition of either MHC class I or Class II and peptide leads to which of the following outcomes?
Positive selection and expression of both CD4 and CD8 on the cell surface
Failure of positive selection and therefore death by neglect (apoptosis).
Positive selection and expression of only CD4 on the cell surface.
Negative selection (apoptosis).