Indicate which of the following mutations will produce a local impact in altering gene expression (local impact refers to altering gene expression of only the mutant gene) in a cell that is homozygous for the gene mutation described? A. A deletion of the promoter sequence of the gene encoding the general transcription factor TFIIA B. A 2 base-pair insertion in the 5'UTR of the SRE gene, which encodes a protein involved in breaking down cholesterol C. A nonsense mutation in exon 1 of the ACO gene, which encodes a protein that functions in cell movement D. B and C E. All of the above This question was created or adapted by your instructor.
Added by Beth C.
Close
Step 1
A "local impact" is defined as altering the gene expression of *only the mutant gene*. This means we are looking for a mutation that specifically affects the expression of the gene in which the mutation occurs, without necessarily affecting other genes or global Show more…
Show all steps
Your feedback will help us improve your experience
Sri K and 62 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Which of the mutations that follow are likely to be recessive lethal mutations (i.e. mutations causing lethality when they are the only alleles present in an individual) in humans? Explain your reasoning. a. Deletion of the U1 genes. b. A single base-substitution mutation in the U1 gene that prevented the U1 snRNP from binding to the 5'-GU-3' sequence found at the 5' splice junctions of the introns. c. Deletion within the intron of the β-globin. d. Deletion of four bases at the end of intron 2 and three bases at the beginning of exon 3 in β-globin.
Sri K.
Complete the following sentence. A ______________ mutation in a receptor codon would not prevent its normal function. a-Silent mutation b-Missense mutation c-Nonsense mutation d-Deletion 2. From the following statements, choose the most likely effect of deleting two nucleotides in a codon at a receptor binding site? a-The reading frame would be changed, producing a non-functional receptor. b-Changing an amino acid in the binding site will cause the ligand to no longer be compatible with the receptor. c-There will be no change; the receptor will bind the ligand. d-The receptor will bind another ligand instead. 3. The mutation of a gene encoding a transcription factor occurs in a fat cell. The synthesis of several proteins linked to lipid metabolism is reduced. Which of the following best explains what happened in controlling the expression of these proteins? a-The mRNA must be polycistronic to allow coordinated expression of genes. b-Proteins linked to fat metabolism were labeled with ubiquitin and then degraded by lysosomes. c-Proteins linked to fat metabolism are encoded by the same mRNA. d-The coordinated expression of these proteins is controlled by the mutated transcription factor.
a bacteriologist induces a mutation in a gene for a 100 amino acid protein. upon further analysis, it was found that when the mutant gene is expressed, a 50 amino acid mutant protein is made. the mutant protein consists of the first 50 amino acids of the wild type protein. This mutant could be the result of... a. a single base pair mutation b. a deletion of one nucleotide c. an insertion of one nucleotide d. a deletion of 4 nucleotides e. all of the above
Adi S.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
18,000,000+
Students on Numerade
Trusted by students at 8,000+ universities
Watch the video solution with this free unlock.
EMAIL
PASSWORD