Inoculating the mouse brain with an extract from a person with Creutzfeldt-Jakob Disease (CJD) does not result in the propagation of the prion. What is the explanation for this? Group of answer choices Prion transmission requires passage through the gastrointestinal tract The species barrier prevents transmission CJD results in several prion strains of varying transmissability CJD is not a prion disease
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Mad cow disease, or bovine spongiform encephalopathy, appears to be caused by a novel infectious agent: a protein that replicates by causing related proteins to modify their structure from a harmless shape to a dangerous one. These prions (short for "proteinaceous infectious particles"] also appear to be the cause of several other spongiform encephalopathy diseases, such as scrapie in sheep, and kuru and Creutzfeldt-Jakob disease in humans. Which of the following observations or experiments would not support the hypothesis that a prion causes spongiform encephalopathy? (a) The brains of many sheep with scrapie contain prion proteins, but the brains of most sheep without scrapie do not. (b) There is a high incidence of kuru in populations of people who consume brain tissue from prion-infected animals. (c) Coyotes that feed on cows with mad cow disease do not subsequently develop spongiform encephalopathy. (d) When introduced into sheep brain cells in culture, prions cause the normal proteins to change shape into dangerous prion proteins. (e) When prions are fed to sheep, most of them subsequently develop scrapie, whereas sheep not fed prions do not develop scrapie.
Why is the transmission of a prion not reliant upon genes made of DNA or RNA? a. DNA or RNA, though present, is not transmitted when a prion causes infection. b. The prion does not contain DNA or RNA. c. Only parts of DNA or RNA are transmitted in a prion. d. More of protein and less of DNA or RNA is transmitted.
Which of the following is NOT true of prions? Prions responsible for "mad cow disease" can cause a similar disease in humans. Prions can be transmitted by consumption of dried food or cooked food. Prions that cause spongiform encephalopathies have a different amino acid sequence from PrPc. Prions replicate by converting normal host prion proteins into abnormal prion proteins. All of the answer choices are correct.
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