John Gurdon won the Nobel prize in physiology or medicine for his pioneering work on cloning embryos. His work showed that A. frog ES cells are pluripotent B. Human ES cells could be reprogrammed to produce a frog C. A human iPsc nucleus could be used to produce a new frog D. An adult frog skin cell nucleus could be reprogrammed to produce a new frog
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He is known for his research in developmental biology, particularly in the area of cloning and nuclear reprogramming. Show more…
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Somatic cell nuclear transfer: (select all answers that apply): a) was pioneered by Shinya Yamanaka b) is a technique that de-differentiates cells via the expression of just four transcription factors (Klf4, Oct4, Sox2, and c-Myc) c) was the basic approach used to clone "Dolly the sheep" d) involves the fusion of a somatic cell with an ES cell e) was first demonstrated by transferring a mouse fibroblast nucleus into an enucleated Xenopus oocyte
Madhur L.
Although quite inefficient, cloning by nuclear transplantation can be successful, as exemplified by the cloning of the famous Dolly. Such success implies that: A. Nuclei can be completely reprogrammed by cytoplasmic factors in a foreign cytoplasm. B. Epigenetic changes in somatic cells are functionally irreversible. C. Even a differentiated nucleus contains a complete genome, capable of supporting the development of an entire organism. D. All of the above.
Adi S.
Dolly, a sheep, was an example of reproductive (germline) cloning. Required to perform this process was: a. implantation of uterine cells from one strain into the mammary gland of another. b. fusion of the mammary cell from one strain with an enucleated egg of another strain. c. fusion of an egg from one strain with the egg of a different strain. d. fusion of an embryonic diploid cell with an adult haploid cell. e. fusion of two nucleated mammary cells from two different strains.
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