1. List the chromosomal and/or DNA abnormalities of following tumors A. Follicle center lymphoma t(14;18) IgH/bcl-2 B. Mantle cell lymphoma t(11;14) bcl-1 C. Philadelphia chromosome D. Burkitt's Lymphoma [t(8;14) c-myc/IgH] [t(2;8) kappa/c-myc] [t(8;22) c-myc/lambda] 2. Explain two most important tests used nowadays to detect treatment effectiveness/predict prognosis for HIV infection 3. What is MHC (HLA) A. Where is HLA located B. Three classes of HLA and expression location (type of cells) C. Importance to have HLA gene classes in human 4. List four classes of grafts in human
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Follicle center lymphoma (14;16): This chromosomal abnormality refers to a translocation between chromosomes 14 and 16. It is commonly found in follicle center lymphoma, a type of non-Hodgkin lymphoma. Show more…
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4. Vogelstein et al. investigated allelic deletions in colorectal tumors at three different chromosomal locations. The data is presented in Table 3. In 1988 the genes of significance located on 5q, 18q, and 17p had not yet been identified. What broad class of genes are most likely located in these regions of chromosome loss? Explain your reasoning. Table 3. Allelic Deletions in Colorectal Tumors (modified from Vogelstein et al (1988)) Chromosome | Adenoma Class I percent tumors | Adenoma Class II with deletion | Adenoma Class III (no. analyzed) | Carcinoma --- | --- | --- | --- | --- Chromosome 5q | 0 (34) | 29 (17) | 29 (14) | 36 (58) Chromosome 18q | 13 (23) | 11 (18) | 47 (17) | 73 (56) Chromosome 17p | 6 (32) | 6 (18) | 24 (17) | 75 (60) * Number of tumors that were informative for one or more of the markers on the indicated chromosome.
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