A 2-year-old toddler, Paul, was brought to the emergency room at the local children’s hospital. His mother indicated he had diarrhea and was vomiting and seemed to be breathing fast. It was determined that the toddler was dehydrated. Blood test results: - plasma HCO?? = 20 mmol/L (normal = 24 mmol/L) - arterial PCO? = 40 mm Hg (normal = 40 mm Hg) 5. Blood test results indicated that Paul had an acid-base disturbance. Is he in acidosis or alkalosis? Would his plasma pH be normal, high or low? Respiratory or metabolic? How does Paul’s fast breathing contribute to the results? Justify your answer. 6. Paul received oral rehydration therapy that successfully treated his dehydration and corrected his acid-base condition. If Paul had not been treated so rapidly, his kidneys would have tried to compensate for his condition. What would be the appropriate renal responses to counteract Paul’s condition? Make sure to discuss: • The actions of type A or type B intercalated cells • Reabsorption and secretion of H? and HCO?? • The effects on Paul’s plasma [H?] and pH
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- Measured: plasma HCO3- = 20 mmol/L (normal ≈ 24 mmol/L). Arterial PaCO2 = 40 mm Hg (normal ≈ 40 mm Hg). - Clinical history: diarrhea (major cause of bicarbonate loss), vomiting, dehydration, and mother reports he is breathing fast. Show more…
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Madhur L.
PART B A 45-year-old man, Paul, visiting from out of town arrives at the emergency room having an asthma attack caused by pollen. Blood drawn before treatment showed the following: - blood HCO3⁻ = 30 mmol/L (normal = 24 mmol/L) - arterial PCO₂ = 70 mm Hg (normal = 40 mm Hg) 7. Use the Henderson-Hasselbach equation provided below to calculate Paul’s arterial pH. Show your work and all your calculations [5 marks]. Henderson-Hasselbach equation: pH = 6.1 + log (HCO3⁻ ⁄ (0.03 x PCO₂)) 8. Use your calculations from question #7 and the Paul’s medical history given above to determine his acid-base condition. Is he in acidosis or alkalosis? Respiratory or metabolic? Justify your answer [10 marks]. - Make sure to link Paul’s arterial PCO₂ to plasma [H⁺], plasma pH, and his acid-base disturbance. 9. What would be the appropriate renal responses to counteract Paul’s condition [10 marks]? Make sure to discuss: - The actions of type A or type B intercalated cells - Reabsorption and secretion of H⁺ and HCO₃⁻ - The effects on Paul’s plasma [H⁺] and pH
The patient was a 5-year-old male who presented to the emergency department (ED) with a 5-day history of fevers up to 39.3
Adi S.
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