Multiple Choice 2 points In which white blood cell disorder will you see purple-grey cytoplasmic granules in the neutrophils? May-Hegglin anomaly Chediak-Higashi syndrome Pelger-Huet anomaly Alder's anomaly
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Sukhada S.
For several years, Hans Nachtsheim investigated an inherited anomaly of the white blood cells of rabbits. This anomaly, termed the Pelger anomaly, is the arrest of the segmentation of the nuclei of certain white cells. This anomaly does not appear to seriously burden the rabbits. a. When rabbits showing the Pelger anomaly were mated with rabbits from a true-breeding normal stock, Nachtsheim counted 217 offspring showing the Pelger anomaly and 237 normal progeny. What is the genetic basis of the Pelger anomaly? b. When rabbits with the Pelger anomaly were mated with each other, Nachtsheim found 223 normal progeny, 439 with the Pelger anomaly, and 39 extremely abnormal progeny. These very abnormal progeny not only had defective white blood cells, but also showed severe deformities of the skeletal system; almost all of them died soon after birth. In genetic terms, what do you suppose these extremely defective rabbits represented? Why were there only 39 of them? c. What additional experimental evidence might you collect to test your hypothesis in part $b$ ? d. In Berlin, about 1 human in 1000 shows a Pelger anomaly of white blood cells very similar to that described for rabbits. The anomaly is inherited as a simple dominant, but the homozygous type has not been observed in humans. Based on the condition in rabbits, why do you suppose the human homozygous has not been observed? e. Again by analogy with rabbits, what phenotypes and genotypes would you expect among the children of a man and woman who both show the Pelger anomaly? (Data from A. M. Srb, R. D. Owen, and R. S. Edgar, General Genetics, 2 nd ed. W. H. Freeman and Company, $1965 .)$
Match each cell type with its corresponding description Neutrophils Band neutrophils Pelger-Huet anomaly Eosinophils Basophils Lymphocytes Reactive lymphocytes Neoplastic lymphocytes Are also called "stabs." Have abundant gray-blue cytoplasm, possibly with clear vacuoles. These cells have prominent nucleoli. Contain numerous purple granules and a round nucleus. Up to 50% may be intermediate to large size in cows. Have a twisted or irregular nucleus in dogs. Have more intensely basophilic cytoplasm and may have a perinuclear clear area. Contain numerous, large, brightly staining granules in horses. The predominant circulating white blood cell in dogs, cats, and horses. A congenital or acquired defect most often seen in dogs.
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