Negative selection of thymocytes that bind too tightly to self-proteins is mediated largely by medullary thymic epithelial cells (mTECs), a cell type that ____________________. Group of answer choices has the ability to undergo recombination of antigen receptor genes has the ability to express host proteins found only in the thymus can be found in most mammalian organs has the ability to express host proteins found in distal organs and tissues none of the above
Added by Jacob G.
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Step 1: Identify the role of medullary thymic epithelial cells (mTECs) in negative selection: they present self-antigens, including tissue-restricted antigens, to delete T cells that bind too tightly to self. Show more…
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Promiscuous gene expression controlled by AIRE expressed by mTECs leads to the deletion of autoreactive thymocytes. Promiscuous gene expression controlled by Fezf2 expressed by mTECs leads to the deletion of autoreactive thymocytes. Negative selection leads to the deletion of Tregs. Negative selection ensures self-tolerance. None of the above.
Sri K.
In T-cell development, negative selection selects what? a. T-cells that would be more useful as B-cells b. thymocytes that have too great a binding affinity for MHC/self peptide c. T-cells with receptors that would recognize negatively charged peptides d. T-cells that should be fast-tracked to inducing neuron apoptosis e. only recognize antigen when it is presented on self-MHC molecules
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All of the following are true about thymus Except: a. It is the organ where T cell precursors mature. b. It provides positive selection and negative selection for T cells. c. Absent in newborns will not affect B cell mediated immunity. d. Absent in newborns will cause T cell mediated immunity disorder.
Joanna Q.
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