Not at all. Dark-colored urine is caused by bilirubin. Gallstones that obstruct the common bile duct cause increased bilirubin, which is excreted primarily in the liver. Hepatocytes normally produce bilirubin, which is excreted primarily in the blood and tissues. Jaundice is caused by accumulation of bilirubin in the blood and tissues. In a person who has dark skin, the best place to see jaundice is the sclera.
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Bilirubin is generated when the body breaks down red blood cells. Despite having two carboxylic acid functional groups, bilirubin is highly lipophilic and is insoluble in water and methanol. Why is bilirubin lipophilic? Secondly, bilirubin must undergo conjugative metabolism for its elimination. Accumulation of bilirubin is highly toxic. What is the mechanism of bilirubin toxicity?
Madhur L.
Assertion: Jaundice is the yellowish discolouration of eye and skin. Reason: It occurs due to the deposition of bile pigments.
A person with gallstones may have jaundice. Explain the link between gallstones and jaundice.
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