One of the key considerations when developing antibiotics is targeting bacteria without harming the infected individual. Protein synthesis in bacteria and eukaryotes are different enough that this is a good target for antibiotics that inhibit translation machinery. In fact, antibiotics that inhibit bacterial translation can do so in different ways. Select the specific mechanisms by which certain antibiotics interfere with translation. inhibits cell structural integrity by interfering with peptidoglycan synthesis binds to the ribosome and blocks subsequent translation binds to the 50s ribosomal subunit interferes with gyrase, which relaxes supercoiled DNA
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Inhibiting cell structural integrity by interfering with peptidoglycan synthesis is a method used by some antibiotics, but it does not directly interfere with translation. Peptidoglycan is a component of the bacterial cell wall, not the protein synthesis Show more…
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