The effect of a drug called DNP on the lifespan of mice is shown in the graph below. Each point represents the death of a single mouse. Control DNP 1 100 2 120 3 140 Age (weeks) In the 1930s, DNP was introduced as a diet drug until it was banned from human use because of adverse side effects when high concentrations of the drug were used. These included increased respiration and even death. Propose an explanation for the side effects based on the effect DNP has on the proton gradient. Drag the terms on the left to the appropriate blanks on the right to complete the sentences: NAD The increased respiration likely arises from an elevated demand for glucose to drive electron transport and address the efficiency of ATP synthesis. Deain is likely being produced to keep cells alive due to insufficient citrate reduced increased ATP.
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The production of ROS can be reduced using drugs that allow protons to freely pass through the inner membrane. The effect of a drug called DNP on the life span of mice is shown in the graph below. Each point represents the death of a single mouse. At what age is the difference in survival between the DNP-treated and the untreated control the greatest?
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