Part 3. Lipase Mechanism • (9 pts) Add arrows and missing tetrahedral intermediates in mechanism. Asp176 OH Asp176 His263 Tetrahedral Intermediate Ser152 His263 Ser152 OAcyl OAcyl Phe77 Leu153 Asp176 OAcyl OAcyl Phe77 Leu153 Asp176 His263 OAcyl OAcyl H2O His263 Ser152 Ser152 HO OAcyl OAcyl Phe77 Phe77 Leu153 Leu153 Asp176 OH Asp176 Tetrahedral Intermediate His263 His263 OH Ser152 HO OH Phe77 Phe77 Leu153 Leu153 • (1 pts) The formation of the serine ester is an example of (circle one): o Acid/Base catalysis o Group Transfer o Electrostatic Stabilization /10
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However, I can explain the mechanism of lipase. Lipase is an enzyme that catalyzes the hydrolysis of fats (lipids). The mechanism involves the following steps: Show more…
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Part 3. Lipase Mechanism Add arrows and missing tetrahedral intermediates in mechanism. Asp176 His263 Ser152 OAcyl OAcyl Phe77 Leu153 Tetrahedral Intermediate H2O The formation of the serine ester is an example of (circle one): Acid/Base catalysis Group Transfer Electrostatic Stabilization /10
Sri K.
a. Draw the structure of the tetrahedral intermediate INITIALLY FORMED in the reaction shown. You do not have to consider stereochemistry. Do not include counter-ions, e.g., Na+, I-, in your answer. In cases where there is more than one answer, just draw one. b. Draw the structures of the final acyl transfer products obtained. You do not have to consider stereochemistry. Draw organic products only. Draw the neutral form of the products; no charges. Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. Separate multiple products using the + sign from the drop-down menu.
Nicole K.
1.a. (7 pts) Below is the carbon-carbon forming step for a transketolase reaction. Add curved arrows to show reasonable electron flow for this reaction. Add any required general acids or bases.
Madhur L.
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