People with beriberi, a disease caused by thiamine deficiency, have elevated levels of blood pyruvate and a-ketoglutarate, especially after consuming a meal rich in glucose. How are these effects related to a deficiency of thiamine? (2 pts.)
Added by Shirley P.
Close
Step 1
Step 1: Thiamine is a co-factor for the enzyme pyruvate dehydrogenase, which is responsible for converting pyruvate to acetyl-CoA. Show more…
Show all steps
Your feedback will help us improve your experience
Shaiju T and 57 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Beriberi is a nutritional deficiency disease resulting from inadequate thiamine in the diet. Individuals lacking thiamine accumulate two metabolites as a consequence of eating sugar – what are they? Please explain the reasoning behind the answer.
Adi S.
Individuals with a thiamine-deficient diet have relatively high levels of pyruvate in their blood. Explain this in biochemical terms.
Beriberi is a disease caused by a deficiency of vitamin $\mathrm{B}_{1}$ (thiamine) in the diet. Thiamine is the precursor of thiamine pyrophosphate. In view of what you have learned in this chapter, why is it not surprising that alcoholics tend to develop this disease?
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD