Predict whether TH-cell proliferation or CTL-mediated cytolysis will occur with the following mixtures of cells. The CD4+ TH cells are from spike protein-primed mice, and the CD8 CTLs are from coronavirus-infected mice. Briefly explain your answer. 1. H-2k TH cells + spike protein-pulsed H-2k macrophages 2. H-2k T cells + spike protein-pulsed H-2k macrophages treated with chloroquine 3. H-2k TH cells + spike protein-pulsed H-2kb macrophages treated with chloroquine 4. H-2k TH cells + spike protein-pulsed H-2 macrophages 5. H-2k T cells + spike protein-pulsed H-2 macrophages treated with chloroquine 6. H-2 CTL + coronavirus-infected H-2k macrophages 7. H-2 CTL + coronavirus-infected H-2k macrophages treated with emetine 8. H-2k CTL + coronavirus-infected H-2 macrophages 9. H-2k CTL + coronavirus-infected H-2d macrophages treated with emetine 10. H-2 CTL + coronavirus-infected H-2k/d macrophages 11. H-2k CTL + coronavirus-infected H-2kd macrophages treated with emetine
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H-2k TH cells + spike protein-pulsed H-2k macrophages: In this case, TH-cell proliferation is likely to occur. TH cells recognize antigens presented by macrophages and help in the activation and proliferation of other immune cells. Show moreā¦
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6) This T cell restriction in (5) is because of a. Negative selection of thymocytes by thymic cortical epithelial cells b. Negative selection of thymocytes by thymic medullary epithelial cells c. Positive selection of thymocytes by thymic cortical epithelial cells d. Negative selection of thymocytes by macrophages and dendritic cells 7) H-Y antigens are only found in cells of male mammals such as mice. Double positive T cells with a transgenic TCR specific for H-Y (male) antigen on an MHC class I protein present in that given strain of mouse A. would develop normally in male and female mice B. would develop into both CD4+ T cells and CD8+ T cells in female mice but would not develop into mature T cells in male mice. C. would develop into CD4+ T cells and CD8+ T cells in female mice and would develop into CD4+ T cells in male mice. D. would develop into CD8+ T cells in female mice but would not develop into mature T cells in male mice. E. would develop into CD8+ T cells in both female and male mice. 8) What is the correct chronological order for T cell expression during Ī±:Ī² T cell development of the following proteins? a- CD44, Pre T Ī±, Ī± chain, Ī² chain, CD4 CD8 b- CD44, Ī² chain, Ī± chain, Pre T Ī± ( pTĪ±) c- CD44, Ī² chain, pTĪ±, Ī± chain
Sri K.
Working out the rules by which $\mathrm{T}$ cells interact with their target cells was complicated. Some of the key observations came from studying the way cytotoxic T cells killed cells infected with choriomeningitis virus (LCMV). Cytotoxic T cells derived from mice expressing "k-type" class I MHC proteins lysed LCMV-infected cells expressing the same k-type MHC protein, but they did not lyse infected cells from mice expressing "d-type" class I MHC proteins (Figure $Q 24-2$ ). Similarly, cytotoxic T cells from d-type mice lysed infected d-type cells, but not infected k-type cells. LCMV can kill both k-type and d-type mice. A. If homozygous d-type mice were bred to homozygous k-type mice to generate d-type/k-type heterozygous progeny, would you expect that cytotoxic T cells from these heterozygotes, when infected with ICMV, to be able to lyse infected d-type cells? How about infected k-type cells? Explain your answers. B. Oddly enough, ICMV infection does not kill mice that lack a thymus-such as "nude" mice, so called because they also lack hair. If a thymus is transplanted back into a nude mouse, it will die when infected with LCMV. Suppose that a d-type/k-type heterozygous nude mouse was given a thymus from an d-type donor. Would you expect its cytotoxic T cells to be able to lyse infected d-type cells? How about infected k-type cells? Explain your answers.
Which of the following statements is/are true about T-cell selection and help explain your answer for whether T cells from B mice (the recipient strain) that received bone marrow from K strain donors would, or would not, proliferate in the this assay? these thymocytes develop in an H-2b thymus before selection, thymocytes from these mice produce TCRs specific for only H-2k before selection, thymocytes from these mice produce some TCRs that can interact with H-2k and some that can interact with H-2b MHC before selection some thymocytes from these mice produce TCRs that can interact with other MHC alleles that are not H-2k or H-2b positive selection would only select for thymocytes with TCRs capable of interacting with H-2b MHC MCC is presented as a self-antigen in the thymus of these mice After selection, none of the TCRs in these mice can respond to MCC on H-2b After selection, some of the TCRs in these mice can respond to MCC on H-2b After selection, TCRs in these mice cannot respond to MCC presented on I-Ak After selection, some TCRs in these mice can respond to other antigens presented on I-Ak
Adi S.
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