1. Signals are released by unattached kinetochores and cause MAD to bind to CDC20 2. When all kinetochores are attached MAD releases CDC20 and CDC20 binds to APC 3. The APC/CDC20 complex ubiquitinates Securin ***Normally securin is bound to separase 4. Securin is destroyed, and Separase is released 5. Separase destroys cohesin 6. Chromatids separate, and mitosis proceeds to anaphase MAD CDC20 APC Separase ubiquitin Securin APC (anaphase promoting complex) T/F: MAD is a tumor suppressor protein.
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Step 1: MAD (Mitotic Arrest Deficient) attaches itself to the kinetochore. Show more…
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