1. Signals are released by unattached kinetochores and cause MAD to bind to CDC20 2. When all kinetochores are attached MAD releases CDC20 and CDC20 binds to APC 3. The APC/CDC20 complex ubiquitinates Securin 4. Securin is destroyed, and Separase is released 5. Separase destroys cohesin 6. Chromatids separate, and mitosis proceeds to anaphase MAD CDC20 APC CDC20 Separase ubiquitin Securin APC (anaphase promoting complex) ***Normally securin is bound to separase T/F: A mutant CDK that is active in the absence of its cyclin binding partner could contribute to the development of cancer.
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