Q2.25. Which aspect of DNA replication is affected by the drug? • Making primers • Extending primers with DNA • Replacing RNA in primers with DNA • Sealing nicks Check Answer Q2.26. What effect would the drug have on a cell? • The cell would have many mutations in its DNA. • The cell would be unable to replicate DNA. • The cell would replicate DNA very slowly, using DNA polymerase I instead of III. Check Answer
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You add a drug that stops DNA Polymerase I activity in bacterial cells. Which of the following would happen? A. Extension of telomeres would stop B. Nothing. DNA Polymerase I does not participate in DNA replication C. Extension of the leading strand would stop at the replication fork D. Replacement of pre-existing RNA primers on the lagging with DNA nucleotides would stop A mutation has occurred such that the ends of all the chromosomes in the affected individual shorten very quickly. There are no other effects on DNA replication. Which of the following could explain this? A. A mutation in the nucleotide sequence of a telomere at the end of one chromosome B. A mutation in the gene encoding part of the telomerase enzyme C. A mutation in the proofreading ability of DNA Polymerase D. A mutation in the excision base repair mechanism
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7. DNA replication : a.) You have a drug that blocks the activity of Primase. What will happen to DNA replication upon administration of the drug? Be specific, what exactly won't happen and as a result, what will be affected. b. ) You have a drug that blocks the activity of topoisomerase. What will be the effect ? Be specific .
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PCR Primers: (I) 5'GCCTACTT3' and (II) 5'-CCGGATCC-3' 5'-AGGCCTGCTCGCCTACTTAAGGGCCTACGATGCAGCCTGGATCCGGATCG-3' a) Which primer (I) or (II) would bind to the above strand? b) Where would the primer bind, please underline the 8 bases? c) You now add DNA polymerase (Remembering DNA polymerases produce new DNA 5' to 3'), dNTPs, and MgCl2. What would the sequence of the new strand of DNA look like (include primer)? 5'- d) You now denature the double stranded DNA. e) Which primer (I) or (II) would bind to the new strand in answer c? f) Where would the primer bind to the new strand in answer c, please underline the 8 bases? g) You now add DNA polymerase (Remembering DNA polymerases produce new DNA 5' to 3'), dNTPs, and MgCl2. What would the sequence of the resulting strand of DNA look like? 5'- With multiple rounds almost all the DNA will become the resulting strand.
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