00:01
Hello everyone, here we have the question about ingelman syndrome which is a genetic disorder caused by the mutation of the gene ubiquitin protein ligase that is ube3a gene which is present on the chromosome 15.
00:20
The point is that it shows the genomic imprinting while in inheritance.
00:27
So in this case if the mutated gene is inherited from the mother then only the ingelman syndrome is seen.
00:52
Now here we have the statements we are supposed to find out which one is correct.
00:58
Deletion of the paternal gene copy but normal maternal gene copy could produce a syndrome.
01:06
Deletion of paternal gene does not have any effect so this is false.
01:16
The next statement says that the children of affected females have 50 % chances of showing the syndrome.
01:24
This is true because the mutated gene if inherited from mother the children can show the syndrome so this is true.
01:44
The third statement says neotic non -junction of normal paternal chromosome 15 accompanied by loss of the maternal chromosome 15 in the zygote could produce a syndrome.
01:58
This is true as the loss of the chromosome 15 maternal chromosome 15 result into the loss of ube3a gene so this would be resulting into the syndrome...