QUESTION 15 1-year-old hispanic boy is diagnosed with osteogenesis imperfecta. A condition that results in bones breaking easily. This is due to weaker collagen proteins analogous to tamin C deficiency (scurvy). Which one of the following compounds is most likely missing in the boy's bone biopsy? serine glycine alanine glutamate hydroxyproline
Added by James B.
Close
Step 1
This is due to defects in collagen synthesis. Vitamin C deficiency (scurvy) also affects collagen synthesis. Show more…
Show all steps
Your feedback will help us improve your experience
Sukhada S and 81 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
In scurvy, which of the following amino acids is not present in the collagen molecule? a. hydroxytyrosine b. hydroxyalanine c. hydroxytryptophan d. hydroxyproline
Sukhada S.
Scurvy and Collagen. Scurvy is a disease that until the nineteenth century was common among sailors and others whose diets were deficient in vitamin $C$ (ascorbic acid). Individuals with scurvy suffer from various disorders, including extensive bruising, hemorrhages, and breakdown of supporting tissues. Ascorbic acid serves as a reducing agent responsible for maintaining the activity of prolyl hydroxylase, the enzyme that catalyzes hydroxylation of proline residues within the collagen triple helix, which is required for helix stability. (a) Based on this information, postulate a role for hydroxyproline in collagen triple helices, and explain the sequence of events leading from a dietary vitamin C deficiency to symptoms such as bruising and breakdown of supporting tissues. (b) Can you guess why sailors are no longer susceptible to scurvy? And why do you think British sailors are called "limeys" to this day?
Sri K.
Mutations in the genes encoding collagens often have detrimental consequences, resulting in severely crippling diseases. Particularly devastating are mutations that change glycines, which are required at every third position in the collagen polypeptide chain so that it can assemble into the characteristic triple-helical rod (see Figure $20-9$ ). Would you expect collagen mutations to be detrimental if only one of the two copies of a collagen gene is defective?
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
18,000,000+
Students on Numerade
Trusted by students at 8,000+ universities
Watch the video solution with this free unlock.
EMAIL
PASSWORD