Which mutation would likely have the largest effect on an enzyme? A. A frameshift mutation near the end of a gene B. A substitution that produces a stop codon at the beginning of a gene C. An insertion of three nucleotides near the end of the gene D. A deletion of three nucleotides near the end of the gene
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Mutations can affect the structure and function of proteins, including enzymes. A frameshift mutation occurs when nucleotides are inserted or deleted in a DNA sequence, causing a shift in the reading frame. This can lead to a completely different amino acid Show more…
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There is a mutation where a codon changes from 5' UGU 3' to 5' UGA 3'. What kind of mutation is this? Silent (neutral) mutation Missense mutation Nonsense mutation Frameshift mutation
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5. Click on a DNA base in the first codon and make a substitution mutation that causes a silent mutation. Remember that silent mutations change the DNA codon but result in the same protein (hint: think wobble base). Substitution mutation Insertion mutation Deletion mutation 6. Click on Show Protein to ensure the mutation really is silent. Take a screenshot of your new protein and insert it here. Indicate on the original strand of DNA below the mutation you made. Make sure to use a different color to indicate the mutation. 3’-ATGCCAGGCGGCGAGAGCTTGCTAATTGGCTTATAG-5’ Some substitution mutation result in a malfunctioning protein but others do not. Why is this?
Which of the following mutations would most likely have the severest consequences: Explain your reasoning. a. A change in amino acid recognition of an aminoacyl-tRNA synthetase b. A frame shift mutation at the end of the coding sequence of a gene c. A mutation at a splice junction
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