Question: You have been asked to design a drug to inhibit BCR-ABL in an effort to treat CML. Using your knowledge of enzyme-catalyzed reactions and the BCR-ABL kinase, propose a drug development strategy to combat CML. *Regular Abl protein is regulated by other molecules. *BCR-ABL has a mutant kinase that leads to cancer.
Added by Joseph U.
Step 1
Understanding the Structure: The first step in designing a drug to inhibit BCR-ABL would be to understand the structure of the BCR-ABL kinase. This would involve studying the protein's structure, its active site, and the mechanism by which it catalyzes reactions. Show more…
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