See if you can determine the overall effect of DNP by observing the cyclist as she takes a "trial" dose. Start the cyclist moving with the EFFORT slider. Observe the displays underneath her. She is not yet taking DNP. Select DNP present: Yes to give the cyclist a nonlethal dose of DNP. Q2.1. Based on what you see, what does DNP do? The cyclist uses much more glucose to maintain the same speed. The cyclist can go faster on the same amount of glucose. The cyclist produces less $CO_2$. The cyclist cannot use $O_2$.
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This means that it prevents the production of ATP from the electron transport chain, but it does not prevent the electron transport chain from running. Show more…
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Question 8 (2 points) What would explain increased body temperature in someone taking DNP? increaesd rate of glycolysis decreased increased ATP to ADP conversion Increaed usage of oxygen Question 9 (2 points) The drug 2,4-dinitrophenol (DNP) makes the mitochondrial inner membrane permeable to H+. The resulting disruption of the proton gradient inhibits the mitochondrial production of ATP. What additional effect would DNP have on the transport of ATP out of the mitochondrial matrix? None, because the inner membrane is permeable to ATP. ATP transport will increase because ATP synthase will be forced to operate in the "reverse" direction. ATP transport will decrease because less ATP will be available to diffuse across the inner membrane. None, because ATP export is not coupled to the movement of protons across the inner membrane. ATP export will decrease because its carrier exploits the difference in voltage across the inner membrane.
Suman K.
2,4-Dinitrophenol (DNP) affects electron transport and oxidative phosphorylation in mitochondria by binding to H+ ions in the intermembrane space, and then, because the 2,4-Dinitrophenol is nonpolar, it diffuses with the H+ ion across the mitochondrial membrane into the cytosol. Explain why the pH in the intermembrane space increases after ingesting DNP. You may draw a diagram if it helps your explanation. People who ingest this compound can suffer from fatigue. Explain all of the changes that would occur in the electron transport chain and oxidative phosphorylation after ingesting DNP and describe why these changes could lead to fatigue. After DNP was discovered in the 1930s, it was used as a dieting drug until it was taken off the market after too many people suffered severe side effects and some died. DNP, however, continues to be used by some bodybuilders because it results in a rapid loss of fat. How does this drug, which affects cell respiration, result in a rapid loss of fat? Think about our discussion in class about how cell respiration is related to other catabolic and anabolic reaction pathways.
Madhur L.
The effect of a drug called DNP on the lifespan of mice is shown in the graph below. Each point represents the death of a single mouse. Control DNP 1 100 2 120 3 140 Age (weeks) In the 1930s, DNP was introduced as a diet drug until it was banned from human use because of adverse side effects when high concentrations of the drug were used. These included increased respiration and even death. Propose an explanation for the side effects based on the effect DNP has on the proton gradient. Drag the terms on the left to the appropriate blanks on the right to complete the sentences: NAD The increased respiration likely arises from an elevated demand for glucose to drive electron transport and address the efficiency of ATP synthesis. Deain is likely being produced to keep cells alive due to insufficient citrate reduced increased ATP.
Adi S.
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