Select the factors that inhibit the pyruvate dehydrogenase complex. increase in $Ca^{2+}$ concentration high concentration of NADH pyruvate inhibition of the regulatory kinase insulin (in the liver and adipose tissue) phosphorylation of $E_1$ (pyruvate dehydrogenase)
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The activity of the pyruvate dehydrogenase complex is also controlled by phosphorylation. Pyruvate dehydrogenase kinase (PDH kinase) catalyzes the phosphorylation of a specific Ser residue on the E1 subunit of the enzyme, rendering it inactive. Pyruvate dehydrogenase phosphatase (PDH phosphatase) reverses the inhibition by catalyzing the removal of this phosphate group. The PDH kinase is highly regulated, and its activity is influenced by various cellular metabolites. Indicate whether the following would activate or inhibit PDH kinase: Inhibit or activate PDK? NAD+ NADH Coenzyme A Acetyl-CoA ADP
Adi S.
The active form of pyruvate dehydrogenase is favored by the influence of all of the following on pyruvate dehydrogenase kinase except A. low $\left[\mathrm{Ca}^{2+}\right]$ B. low acetyl CoA/CoASH. C. high [pyruvate]. D. low NADH/NAD $^{+}$
Ronald P.
What will be the consequence of inhibiting the pyruvate dehydrogenase-specific phosphatase regulatory enzyme? a. The pyruvate dehydrogenase complex will be activated. b. There will be an increase in the concentration of acetyl CoA. c. The production of Citric Acid Cycle metabolites will increase. d. Synthesis of ATP will slow down.
Bryan V.
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