SLE is an autoimmune disease that leads to kidney failure, along with other clinical manifestations. The pathogenesis of this disease involves several mutations in the immune system. Which of the following best describes the reason for disease development?
Added by Kristina R.
Step 1
Step 1: Understand that Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the immune system attacking self-antigens, leading to widespread inflammation and tissue damage, including kidney involvement (lupus nephritis). Show more…
Show all steps
Your feedback will help us improve your experience
Suman K and 65 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the development of autoantibodies specific for DNA and other nuclear antigens. Patients with SLE show a wide variety of symptoms that include anemia, skin rashes, joint and muscle pain, heart problems, and kidney damage. This is considered a systemic autoimmune disease because: a. Different patients have different symptoms. b. All patients have damage to more than one organ. c. The majority of patients have kidney damage. d. The autoantigen targeted by the immune system is not tissue-specific. e. Multiple different tissue-specific autoantigens are recognized in a single patient.
Suman K.
Individuals with the autoimmune disease systemic lupus erythematosus (SLE) produce antibodies to DNA and phospholipids. (a) Explain why normal individuals do not make antibodies to these substances. (b) During a normal response to a viral or bacterial infection, the immune system produces large amounts of antigen-specific antibodies, and the resulting antigen-antibody complexes are subsequently removed from the circulation and degraded. Explain why antigen-antibody complexes accumulate in the tissues of individuals with SLE.
Surprisingly, individuals with defects in the early components of the classical complement cascade (i.e., C1, C2, or C4) suffer from an autoimmune type of kidney damage, rather than from an immunodeficiency leading to increased susceptibility to infections. Why do these complement defects lead to autoimmune kidney damage?
Rahel K.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD