Question

Suppose you are a physician or genetic counselor. Your patient has a family history of Huntington's disease. You collect a sample of the patient's cheek cells and send the sample off for genetic testing using PCR primers that will amplify base pairs 60 to 240 of the sequence shown. Note: Your patient may have fewer or more CAG repeats in this region, but the sequence is otherwise the same. If the PCR products made using your patient's DNA as a template are 186 and 276 base pairs long, what would you tell your patient about the likelihood of developing Huntington's disease? Multiple Choice The patient has two mutant alleles and will develop the disease at an early age. The patient has one wild-type and one mutant allele with fewer than 100 repeats. This person will develop the disease at a late age. The patient has one wild-type and one mutant allele with over 100 repeats. This person will develop the disease at an early age. The patient has two wild-type alleles and will not develop the disease. The patient has one wild-type and one mutant allele. This person is a carrier but will not develop the disease. Suppose you are a physician or genetic counselor. Your patient has a family history of Huntington's disease. You collect a sample of the patient's cheek cells and send the sample off for genetic testing using PCR primers that will amplify base pairs 60 to 240 of the sequence shown. Note that your patient may have fewer or more CAG repeats in this region, but the sequence is otherwise the same. If the PCR using your patient's DNA as a template produces two DNA fragments that are 177 and 192 base pairs long, what would you tell your patient about the likelihood of developing Huntington's disease? Multiple Choice The patient has one wild-type and one mutant allele. This person is a carrier but will not develop the disease. The patient has one wild-type and one mutant allele with fewer than 100 repeats. This person will develop the disease at a late age. The patient has two mutant alleles and will develop the disease at an early age. The patient has two wild-type alleles and will not develop the disease. The patient has one wild-type and one mutant allele with over 100 repeats. This person will develop the disease at an early age.

Suppose you are a physician or genetic counselor. Your patient has a family history of Huntington's disease. You collect a sample of the patient's cheek cells and send the sample off for genetic testing using PCR primers that will amplify base pairs 60 to 240 of the sequence shown. Note: Your patient may have fewer or more CAG repeats in this region, but the sequence is otherwise the same. If the PCR products made using your patient's DNA as a template are 186 and 276 base pairs long, what would you tell your patient about the likelihood of developing Huntington's disease?

Multiple Choice
The patient has two mutant alleles and will develop the disease at an early age.
The patient has one wild-type and one mutant allele with fewer than 100 repeats. This person will develop the disease at a late age.
The patient has one wild-type and one mutant allele with over 100 repeats. This person will develop the disease at an early age.
The patient has two wild-type alleles and will not develop the disease.
The patient has one wild-type and one mutant allele. This person is a carrier but will not develop the disease.

Suppose you are a physician or genetic counselor. Your patient has a family history of Huntington's disease. You collect a sample of the patient's cheek cells and send the sample off for genetic testing using PCR primers that will amplify base pairs 60 to 240 of the sequence shown. Note that your patient may have fewer or more CAG repeats in this region, but the sequence is otherwise the same. If the PCR using your patient's DNA as a template produces two DNA fragments that are 177 and 192 base pairs long, what would you tell your patient about the likelihood of developing Huntington's disease?

Multiple Choice
The patient has one wild-type and one mutant allele. This person is a carrier but will not develop the disease.
The patient has one wild-type and one mutant allele with fewer than 100 repeats. This person will develop the disease at a late age.
The patient has two mutant alleles and will develop the disease at an early age.
The patient has two wild-type alleles and will not develop the disease.
The patient has one wild-type and one mutant allele with over 100 repeats. This person will develop the disease at an early age.

Added by David M.

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